Protein and Proteomics Center for Commercial and Industrial Purposes (ProCCI)

ศูนย์วิจัยโปรตีนและโปรติโอมิกส์เพื่อการพาณิชย์และอุตสาหกรรม

Faculty of Science, Khon Kaen University, 123 Mittraphap Road, Sila Subdistrict, Mueang Khon Kaen District, Khon Kaen 40002
Tel.
Email: Somkly@kku.ac.th
http://procci.kku.ac.th/

Background

The Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Sciences, Khon Kaen University, is a government research center. The ProCCI have been found as the head research center of sciences and biotechnology for over 15 years with much collaboration, including department of Biochemistry, department of Microbiology, and faculty of Pharmaceutical sciences. The emphasized purposes of the ProCCI are to focus on the proteins and enzymes that possess the conspicuous biochemical properties, the obtained knowledge could be benefit in the agricultural and industrial applications, food and biotechnology industrial applications, and medical and pharmaceutical applications. Furthermore, the ProCCI also produced and encouraged many master students, PhD, researchers, and specialists who will contribute and motivate the social impact of Thailand.

Goal & Mission

Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI) is the organization that integrated by the community of researcher from multidisciplinary including, Biochemistry, Microbiology and Pharmacology who has expertise in researching in-depth properties of proteins and enzymes from biological resources of Thailand. Moreover, agricultural raw materials were also use as the resource for increasing the value of waste from industrial plants in order to support the agricultural and industrial application and medical application. The areas of research of ProCCI will create the basic knowledge and applied Knowledge as follows:
1. Study and identify types of proteins and enzymes which is an important active ingredient in biological resource using high throughput techniques in molecular genetics, omic techniques including, Transcriptomics, Proteomics and Metabolomics
2. Study and identify the types of microbes that can produce bioactive compound for industrial application
3. Structural and function study of proteins, peptide and enzymes in term of primary, secondary, tertiary, and quadratic
4. Production of recombinant protein and peptide using prokaryotic (Escherichia coli) and eukaryotic system (Pichia pastoris)
5. Study of biological properties of protein and peptide such as antibacterial, antioxidant, anti-inflammation, anticancer, wound healing and anti-angiotensin converting enzyme (anti-ACE)
6. Study and development of products prototype from active protein/peptide such as nutraceutical, cosmeceutical, medical technology and agricultural medicine.
Moreover, the ProCCI has the cooperation from various agencies within country and abroad. We have been experienced and expertised in many research fields for over 15 years and produced many master students, PhD, researchers, and specialists. The overview of research scope was shown in this figure

Scheme of ProCCI Research

Director

Prof. Dr. Sompong Klaynongsruang

• Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand • Protein and Proteomics Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen, Thailand

Email:
Tel:

Research Team

• Prof. Dr. Sompong Klaynongsruang, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Assoc. Prof. Dr. Sakda Daduang, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand
• Asst. Prof. Dr. Nisachon Jangpromma, Department of Integrated Science, Forensic Science Program, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Asst. Prof. Dr. Nipa Milintawisamai, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Assoc. Prof. Dr. Jaruwan Siritapetawee, Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand
• Assoc. Prof. Dr. Sopon Boonlue, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Assoc. Prof. Dr. Theerasak Somdee, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Assoc. Prof. Dr. Rina Patramanon, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Asst. Prof. Dr. Somporn Katekaew, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Asst. Prof. Wiyada Mongkolthanaruk, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Asst. Prof. Dr. Atcha Oraintara, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
• Dr. Sophida Sukprasert, Chulabhorn International College of Medicine, Thammasat University, Rungsit Campus, Bangkok, Thailand
• Dr. Saowalak Srihongthong, ‎Faculty of Agriculture, Rajamangala University of Technology Isan, Surin Campus, Surin, Thailand
• Dr. Nualyai Yaraksa, Faculty of Science, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand
• Dr. Jinda Jandaruang, Faculty of Science and Technology, Sakon Nakhon Rajaphat University, Sakon Nakhon, Thailand
• Dr. Anuwat Wanthong, Faculty of Science, Mahasarakham University, Mahasarakham, Thailand
• Dr. Sutthidech Preecharram, Faculty of Liberal Arts and Science Kasetsart, Kasetsart University Kamphaeng Saen Campus
• Dr. Anupong Tankrathok, Faculty of Agricultural Technology, Kalasin University, Kalasin, Thailand

Recent Publication

• Anupong Joompang, Nisachon Jangpromma, Kiattawee Choowongkomon, Wisarut Payoungkiattikun, Anupong Tankrathok, Jarupa Viyoch, Kunlathida Luangpraditkun, Sompong Klaynongsruang (2020). Evaluation of tyrosinase inhibitory activity and mechanism of Leucrocin I and its modified peptides. Journal of Bioscience and Bioengineering. (Inpress).
• Wisarut Payoungkiattikun, Anupong Joompang, Suyanee Thongchot, Boonpob Nowichai, Nisachon Jangpromma and Sompong Klaynongsruang (2020). Evidence of multi-functional peptide activity: Potential role of KT2 and RT2 for anti-inflammatory, anti-oxidative stress, and anti-apoptosis properties. Applied Biological Chemistry. 63(5): 2-13.
• Tinnakorn Theansungnoen, Jureerut Daduang, Aroonsri Priprem, Patcharee Boonsiri, Sakda Daduang and Sompong Klaynongsruang (2020). Formulation and evaluation of niosomes encapsulated with KT2 and RT2: antimicrobial and anticancer peptides derived from crocodile leukocyte extract. International Journal of Pharmaceutical Sciences and Research. 11(2): 623-630.
• Tinnakorn Theansungnoen, Nisachon Jangpromma, Preeyanan Anwised, Sakda Daduang, Yoshihiro Fukumori, Azuma Taoka and Sompong Klaynongsruang (2019). Membranolytic effects of KT2 on gram-negative Escherichia coli evaluated by atomic force microscopy. Applied Biochemistry and Microbiology. 55(5): 495-505.
• Napaporn Roamcharern, Wisarut Payoungkiattikun, Preeyanan Anwised, Bancha Mahong, Nisachon Jangpromma, Sakda Daduang and Sompong Klaynongsruang (2019). Physiological Properties and Oxygen Affinity of Glutaraldehyde Polymerized Crocodile Hemoglobin: The New Alternative Hemoglobin Source of Hemoglobin-Based Oxygen Carriers. Artificial Cells, Nanomedicine, and Biotechnology. 47(1): 852–861.
• Prapenpuksiri Rungsa, Piyapon Janpan, Yutthakan Saengkun, Nisachon Jangpromma, Sompong Klaynongsruang, Rina Patramanon, Nunthawun Uawonggul, Jureerut Daduang and Sakda Daduang (2019). Heterologous expression and mutagenesis of recombinant Vespa affinis hyaluronidase protein (rVesA2). Journal of venomous animals and toxins including tropical diseases. DOI: 10.1590/1678-9199-JVATITD-2019-0030.
• Anupong Tankrathok, Arpaporn Punpad, Monrudee Kongchaiyapoom, Sirinthip Sosiangdi, Nisachon Jangpromma, Sakda Daduang and Sompong Klaynongsruang (2018). Identification of the first Crocodylus siamensis cathelicidin gene and RN15 peptide derived from cathelin domain exhibiting antibacterial activity. Biotechnol Appl Biochem. 66(2): 42–152.
• Jiraporn Lueangsakulthai, Nicholas Michael, Theeranan Temsiripong, WatchareeKhunkitti, Sompong Klaynongsruang and Nisachon Jangpromma (2018). Antioxidant and Anti-inflammatory Activities of the Siamese Crocodile (Crocodylus Siamensis) Hemoglobin Hydrolysate Derived from Trypsin and Papain Hydrolysis. Chiang Mai Journal of Science. 46(5): 915-929.
• Siriporn Khueychai, Nisachon Jangpromma, Sakda Daduang and Sompong Klaynongsruang (2018). Effects of alkaline hydrolysis and storage conditions on the biological activity of ostrich egg white. Journal of Food Processing and Preservation. 43(4) : e13921. DOI: 10.1111/jfpp.13921.
• Siriporn Khueychai, Nisachon Jangpromma, Kiattawee Choowongkomon, Anupong Joompang, Sakda Daduang, Mongkol Vesaratchavest, Wisarut Payoungkiattikun, Shinjiro Tachibana and Sompong Klaynongsruang (2018). A novel ACE inhibitory peptide derived from alkaline hydrolysis of Ostrich (Struthio camelus) egg white ovalbumin. Process Biochemistry. 73: 235-245.
• Hathairat Srisong, Sophida Sukprasert, Sompong Klaynongsruang, Jureerut Daduang and Sakda Daduang (2018). Identification, expression and characterization of the recombinant Sol g 4.1 protein from the venom of the tropical fire ant Solenopsis geminata. Journal of Venomous Animals and Toxins including Tropical Diseases. 24:23. doi: 10.1186/s40409-018-0159-6.
• Pornsuda Maraming, Surachai Maijaroen, Sompong Klaynongsruang, Patcharee Boonsiri, Sakda daduang, Jing-Gung Chung and Jureerut Daduang (2018). Antitumor Ability of KT2 Peptide Derived from Leukocyte Peptide of Crocodile Against Human HCT116 Colon Cancer Xenografts. In vivo. 32: 1137-1144.
• Pornsuda Maraming, Sompong Klaynongsruang, Patcharee Boonsiri, Surachai Maijaroen, Sakda Daduang, Jing-Gung Chung and Jureerut Daduang (2018). Antitumor activity of RT2 peptide derived from crocodile leukocyte peptide on human colon cancer xenografts in nude mice. Environmental Toxicology. 33(9): 972-977.
• Surachai Maijaroen, Nisachon Jangpromma, Jureerut Daduang and Sompong Klaynongsruang (2018). KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116
• cells. Environmental Toxicology and Pharmacology. 62: 164-176.
• Santi Phosri, Nisachon Jangpromma, Leng Chee Chang, Ghee T. Tan, Supakit Wongwiwatthananukit, Surachai Maijaroen, Preeyanan Anwised, Wisarut Payoungkiattikun and Sompong Klaynongsruang (2018). Siamese crocodile white blood cell extract inhibits cell proliferation and promotes autophagy in multiple cancer cell lines. Journal of Microbiology and Biotechnology. 28(6): 1007–1021.
• Weeraya Phupiewkham, Lu Qiumin, Wisarut Payoungkiattikun, Threeranan Temsiripong, Ren Lai, Nisachon Jangpromma and Sompong Klaynongsruang (2018). Development and Characterization of Anti-acne gel containing Siamese Crocodile (Crocodylus siamensis) leukocyte extract. Journal of Microbiology and Biotechnology. 28(5): 707-717.
• Anawat Pakdeesuwan, Tomohiro Araki, Wisarut Payoungkiattikun, Lorenz K. Neubert, Nisachon Jangpromma and Sompong Klaynongsruang (2018). Development, characterization and determination of biological properties of crocodile hemoglobin (Crocodylus siamensis) tablets. Journal of Food Biochemistry. DOI: 10.1111/jfbc.12503.
• Tinnakorn Theansungnoen, Patthana Tastub, Nisachon Jangpromma, Nualyai Yaraksa, Theeranan Temsiripong and Sompong Klaynongsruang (2018). Antimicrobial Efficacy of a Combination of Crocodile (Crocodylus siamensis) Leukocyte Extract and Hen Egg Lysozyme. Chiang Mai Journal of Science. 45(2): 797-810.
• Nisachon Jangpromma, Khantheeranut Suttee, Santi Phosri, Tinnakorn Theansungnoen, Jiraporn Lueangsakulthai, Wisarut Payoungkiattikun, Sakda Daduang, and Sompong Klaynongsruang (2018). Antioxidant properties of Crocodylus siamensis blood components on H2O2-induced human skin fibroblast cells. Chiang Mai Journal of Science. 45(3) : 1359-1371.

Research Highlight

Research Collaborations

ProCCI


http://procci.kku.ac.th/

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